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There are new warnings being raised about combining ibuprofen with certain types of blood pressure medications. The combination may lead to permanent kidney damage. A new report from The University of Waterloo suggests that combining ibuprofen with a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure could place people at risk for kidney disease. Diuretics and RSA inhibitors are commonly prescribed together for people with hypertension and are available under various pharmaceutical brand names. Researchers from the University of Waterloo in Ontario examined the interaction of the three types of commonly-used medications. Through the use of computer-simulated drug trials, the research team found that in certain patients with specific medical profiles, the combination of all three medications can lead to acute kidney injury. And, in some cases, the injury caused by the medicine combination can be permanent, the researchers said. The use of computer-simulated drug trials was selected by the University of Waterloo team because it can more quickly provide results than in-human studies. The university noted that its team combined mathematics and computer science in order to offer medical practitioners a head start with issues like drug complications. Anita Layton, professor of applied mathematics at Waterloo and Canada 150 Research Chair in mathematical biology and medicine, noted that not everyone who takes this combination will have these kinds of problems. But, she said the drug combination could be enough of a problem that people should exercise caution. “Diuretics are a family of drugs that make the body hold less water,” Layton said. “Being dehydrated is a major factor in acute kidney injury, and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy. If you happen to be on these hypertension drugs and need a painkiller, consider acetaminophen instead.” Ibuprofen has been known to negatively impact other blood pressure medications, particularly ace inhibitors such as Vasotec or Lotensin, or beta-blockers like Lopressor. The combination of ibuprofen with these drugs has been known to cause heartburn, upset stomach and even ulcers. Ibuprofen on its own can also lead to certain side effects, such as gas or bloating, diarrhea or constipation. The research was presented in the journal Mathematical Biosciences. In addition to Layton, the paper was co-authored by Jessica Leete, Carolyn Wang and Francisco J. López-Hernández.
Clinical Trial Effect of high-dose ibuprofen on 24-hour blood pressure in healthy womenJ M McKenney et al. Drug Intell Clin Pharm. 1987 Jun. AbstractThe nonsteroidal antiinflammatory drug (NSAID) indomethacin has been shown to increase blood pressure in normotensive individuals. The effect of other NSAID on blood pressure has not been as well studied. We evaluated the effects of ibuprofen, an NSAID currently available without a prescription, on 24-hour ambulatory blood pressure in ten young, healthy, normotensive women. Using a randomized, crossover, double-blind design, subjects received ibuprofen 800 mg and a placebo identical in appearance to ibuprofen three times a day for eight days with a washout period between regimens. Subjects were instructed to follow a no-added salt diet during the study. Twenty-four-hour blood pressure monitoring and 24-hour urine collection for prostaglandin E2, creatinine, and sodium were performed on days 1 and 8 of each study week. Tablet counts and a 40 percent reduction in urinary prostaglandin E2 documented compliance with ibuprofen. Ibuprofen had no significant effect on systolic or diastolic blood pressure at any hour during the 24-hour period. Mean blood pressure for the 24-hour period was 112/73 and 111/73 mm Hg on day 1 and 111/73 and 112/73 mm Hg on day 8 for placebo and ibuprofen, respectively. We conclude that ibuprofen at doses as high as 2400 mg/d for up to seven days has no effect on blood pressure in normotensive women. Further studies are needed in hypertensive subjects. Similar articles
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Which is better Tylenol or Advil if you have high blood pressure?Acetaminophen (Tylenol) is often the pain reliever of choice for people with high blood pressure (hypertension) because most other options are types of nonsteroidal anti-inflammatory drugs like ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve), which can raise blood pressure.
How much ibuprofen can I take if I have high blood pressure?Unless your doctor has told you it's OK, do not use over-the-counter ibuprofen, naproxen sodium, or ketoprofen for pain relief. Instead, use a painkiller less likely to increase your blood pressure, like aspirin or acetaminophen. Use as directed.
Can you take blood pressure medication and Advil at the same time?May 6, 2022 -- A study using computer-simulated drug trials found that people taking certain blood pressure medications along with painkillers such as ibuprofen may be risking kidney damage.
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