Stage 4 kidney cancer spread to lungs life expectancy

Survival depends on many factors. No one can tell you exactly how long you will live.

Below are general statistics based on large groups of people. Remember, they can’t tell you what will happen in your individual case. 

Your doctor can give you more information about your own outlook (prognosis). You can also talk about this with the Cancer Research UK nurses on freephone 0808 800 4040, from 9am to 5pm, Monday to Friday.

Survival by stage

There are no UK-wide statistics available for different stages of kidney cancer.

Survival statistics are available for each stage of kidney cancer in one area of England. These figures are for men and women diagnosed between 2013 and 2017. 

Stage 1

More than 85 in 100 people (more than 85%) survive their cancer for 5 years or more after they are diagnosed.

Stage 2

More than 75 out of 100 people (more than 75%) survive their cancer for 5 years or more after diagnosis.

Stage 3

Around 75 in 100 people (around 75%) survive their cancer for 5 years or more after they are diagnosed. 

Stage 4

More than 10 out of 100 people (more than 10%) survive their cancer for 5 years or more after they are diagnosed.

Cancer survival by stage at diagnosis for England
Office for National Statistics, 2019 

Net survival estimates the number of people who survive their cancer rather than calculating the number of people diagnosed with cancer who are still alive. In other words, it is the survival of cancer patients after taking into account that some people would have died from other causes if they had not had cancer. 

Survival for all stages of kidney cancer

There are no overall UK-wide statistics available for different stages of kidney cancer. For people diagnosed with kidney cancer in England between 2013 and 2017:

  • around 80 out of every 100 (around 80%) survive their cancer for 1 year or more after they are diagnosed
  • around 65 out of every 100 (around 65%) survive their cancer for 5 years or more after they are diagnosed
  • more than 50 out of every 100 (more than 50%) survive their cancer for 10 years or more after they are diagnosed

One and five year survival for kidney cancer for England
Office for National Statistics, 2019

These statistics are for net survival. Net survival estimates the number of people who survive their cancer rather than calculating the number of people diagnosed with cancer who are still alive. In other words, it is the survival of cancer patients after taking into account that some people would have died from other causes if they had not had cancer.

About these statistics

The term 1 year survival does not mean that you will only live for 1 year. They relate to the number of people who are still alive 1 year after their diagnosis of cancer.

Some people live much longer than 1 year.

What affects your survival

Your outlook depends on the stage of your kidney cancer when it was diagnosed. This means how big it is and whether it has spread.

The grade of your cancer also affects your outlook. Grade means how abnormal the cells look under a microscope. Low grade tumours tend to grow slower than high grade tumours. Grade 1 is the lowest grade and grade 4 the highest.

Another factor is how well you are overall. Doctors have a way of measuring this. They call it your performance status. A score of 0 means you are fully active and more or less as you were before your illness. A score of 1 means you cannot carry out heavy physical work, but can do everything else. The scores continue to go up, depending on how much help you need.

Performance status score is important in kidney cancer because the cancer can cause general symptoms such as:

  • a high temperature (fever)
  • weight loss
  • extreme tiredness

People who do not have these symptoms have a better outlook than people who do have these symptoms. 

Your age can also affect your outlook. Younger men and women with kidney cancer tend to live slightly longer than older people.

Clinical trials

Taking part in clinical trials can help to improve your outlook if you have kidney cancer. No one is completely sure why this is. It is probably partly to do with your doctors and nurses monitoring you more closely if you are in a trial. For example, you may have more scans and blood tests.

More statistics

For more in-depth information about survival and kidney cancer, go to our Cancer Statistics section.

Kidney cancer is cancer that grows in the kidneys, structures that lie behind the abdominal organs on either side of the spine.

Stage 4 kidney cancer spread to lungs life expectancy

Kidney Cancer. Image Credit: Kateryna Kon/Shutterstock.com

Among adults, the most common form of kidney cancer is renal cell carcinoma, which accounts for around 90 to 95% of primary malignant kidney tumors. About 65,000 cases of renal cell carcinoma are diagnosed each year in the U.S, with cancer affecting slightly more men than women. Individuals affected by the condition are usually aged between 50 and 70 years.

In the majority of cases, symptoms do not present until later on in the course of the disease, when a tumor is already large and may have spread (metastasized). The most common symptom to manifest is hematuria (blood in the urine), followed by flank pain, a palpable mass, and unexplained fever. Hypercalcemia (high blood calcium) is also common and may require treatment.

Renal cell carcinoma is diagnosed based on blood and urine tests, computed tomography (CT) and magnetic resonance imaging (MRI) scans, and sometimes biopsy. The condition is treated with surgery or targeted therapy in cases of early disease, and palliative therapy is the treatment approach in cases of advanced disease.

Kidney cancer staging

Once a physician has diagnosed kidney cancer, they will determine the stage of cancer, which may include further CT scans or other imaging tests.

Kidney cancer is staged as follows:

Stage 1: The tumor is up to 7 cm in diameter and confined to the kidney.

Stage 2: The tumor is larger than 7 cm in diameter but still confined to the kidney.

Stage 3: The tumor has grown beyond the kidney into surrounding tissue and possibly a nearby lymph node.

Stage 4: The tumor has spread beyond the kidney, to more than one lymph node or other parts of the body such as the liver, lungs, or bones.

At the stage of diagnosis, renal cell carcinoma is confined to the kidney in 45% of cases, it is locally invasive in around 33% of cases and it has spread beyond the kidney to other organs in around 25% of cases.

Survival rates

As with many other forms of cancer, the patient outcome depends on the cancer stage at diagnosis, the cancer grade at diagnosis, the patient’s overall health, and age.

The grade of a cancer is decided based on how it appears under microscopic examination. Grading is divided into four stages depending on the size and appearance of the nuclei in the cancer cells. Grade 1 is the lowest grade and grade 4 is the highest grade, with grade 4 tumors more likely to grow rapidly and spread than grade 1 tumors.

Survival is also affected to an extent by age. Younger individuals tend to survive for slightly longer than older individuals, which may be partly due to better overall health, treatments generally being more effective among younger people, and the likelihood of the illness being diagnosed during the earlier stages.

Cancer survival rates are described in terms of the proportion of patients who survive for a given time period after they have been diagnosed with cancer. Generally, survival is talked about in terms of 1-year, 5-year, and 10-year survival rates. However, these are only terms that doctors use and a 5-year survival rate, for example, does not mean a patient will only live for five years.

The number is derived from follow-up research to evaluate the number of people still alive five years after their diagnosis. The risk of cancer returning after five years is minimal, but physicians are reluctant to use the term “cure” due to this small risk of recurrence, and instead, the term 5-year survival is used.

Survival statistics are therefore designed to give an estimate of a patient’s likelihood of survival but do not provide a definitive predictor of how long a patient will live. In the case of kidney cancer, around 72% of those diagnosed live for at least one year after diagnosis, about 56% live for at least 5 years and about 50% live for 10 years or more.

According to the American Cancer Society, the 5-year survival rates after a diagnosis of renal cell carcinoma are as follows:

  • For stage 1 tumors, the patient outlook is generally good if patients are well enough to undergo treatment and the 5-year survival rate is around 90%.
  • For stage 2 tumors, the 5-year survival rate is between 65% and 75%. Those with a low-grade (slow-growing) cancer are more likely to survive and be fit and well.
  • For stage 3 tumors, the 5-year survival rate is between 40% and 70%, with patients more likely to survive if they are fit and well and the cancer is lower grade.
  • For stage 4 tumors, the overall 5-year survival rate is reduced to around 10%, but this depends very much on cancer grade. In cases of low-grade cancer and only local spread, the 5-year survival rate can be as high as 40%.

As symptoms are often absent in the early stages of the disease, renal cell carcinoma is often only detected once it has already reached an advanced stage. If cancer has already spread (or metastasized) to other parts of the body, it cannot be cured and treatment is instead focused on slowing disease progression and alleviating symptoms.

References

  • www.nhs.uk/conditions/cancer-of-the-kidney/Pages/Introduction.aspx
  • www.cancer.org/acs/groups/cid/documents/webcontent/003107-pdf.pdf
  • http://www.uroweb.org/gls/pdf/10_Renal_Cell_Carcinoma_LR.pdf
  • http://www.ajronline.org/doi/pdf/10.2214/AJR.07.3568
  • http://www.nejm.org/doi/pdf/10.1056/nejmra043172
  • http://eu-acme.org/europeanurology/upload_articles/Protzel.pdf
  • http://www.mayoclinic.org/diseases-conditions/kidney-cancer/basics/definition/con-20024753
  • http://www.merckmanuals.com/professional/genitourinary_disorders/genitourinary_cancer/renal_cell_carcinoma.html
  • http://www.cancerresearchuk.org/about-cancer/type/kidney-cancer/treatment/statistics-and-outlook-for-kidney-cancer
  • http://www.cancer.gov/cancertopics/pdq/treatment/renalcell/Patient/page1

Last Updated: Feb 17, 2021

Stage 4 kidney cancer spread to lungs life expectancy

Written by

Sally Robertson

Sally first developed an interest in medical communications when she took on the role of Journal Development Editor for BioMed Central (BMC), after having graduated with a degree in biomedical science from Greenwich University.

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What Happens When kidney cancer spreads to lungs?

Respiratory system Renal cell carcinoma can spread to the lungs. It can block the airways, preventing enough oxygen from getting to your body. Symptoms of metastatic renal cell carcinoma in the lung include a cough, shortness of breath, and pain or pressure in your chest.

How long can you live with kidney cancer that has spread?

If kidney cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the 5-year survival rate is 71%. If the cancer has spread to a distant part of the body, the 5-year survival rate is 14%.

What is the treatment for kidney cancer that has spread to the lungs?

Metastatic kidney cancer most commonly spreads to the lungs, but it can also spread to the lymph nodes, bones, liver, brain, skin, and other areas in the body. This is a systemic disease that usually requires treatment with systemic therapy, such as targeted therapy or immunotherapy.

Is Stage 4 kidney cancer a terminal?

Stage 4 renal cell carcinoma is the most advanced form of this type of cancer. The five-year survival rate for stage 4 renal cell carcinoma that has spread to distant areas of the body is 13%.