When prostate cancer spreads to the lymph nodes what is the prognosis

Finding out that cancer has spread is never welcome news, but don't assume it's the worst news. The 5-year survival rate for prostate cancer that has moved into nearby parts of the body is nearly 100%. Here's what you should know about your treatment and what to expect going forward.

Containing Cancer

When this type of cancer spreads (your doctor may say it has metastasized), it tends to first show up in the tissues or lymph nodes that are closest to the prostate gland. If it's caught and treated at this point, which is known as "regional" stage, your odds of recovery are very good. If it travels further, the cancer usually ends up in your bones. At that point, the chances of survival drop to 29%.

Your doctor will talk to you about your best treatment options.

You may have already had surgery or radiation. Those treatments are sometimes used to target prostate cancer when it's still only in the prostate. When your cancer spreads, your doctor will most likely suggest hormone therapy. That usually means taking medication to lower the amount of androgen hormones (testosterone and DHT) in your body or prevent them from affecting cancer cells. 

A related but rarely used option is surgical castration. The doctor removes your testicles, where most of these hormones are made. If you don’t like the idea of losing them, the doctor can fit you with silicone sacs to insert into your scrotum. They’ll preserve the look and feel.

If hormone therapy doesn't work, you might move on to vaccine therapy. The prostate cancer vaccine is designed to kick-start your immune system so it attacks cancer cells. Or your doctor might suggest chemotherapy. It might be a medication you take by mouth, or something your doctor injects into a vein. 

If prostate cancer has spread to your bones, you'll likely need medication to ease your pain, lower the risk of fractures, and keep your body’s calcium levels steady. It can be dangerous if they go too high or too low. Your doctor might prescribe a drug to help keep your bones strong. You might take corticosteroids to control pain, probably along with a pain reliever. Which pain medicine you get could range from ibuprofen to morphine, depending on how bad your pain is.

Your oncologist might also send you forradiation therapy in an effort to lessen bone pain and kill off cancer cells in your bones.  Or they could inject you with a drug that gives off radiation. These medications are called radiopharmaceuticals.

Signs of Trouble

You might think you’d know it if your cancer has spread, but that's not always true. Most men with advanced prostate cancer don't have any symptoms.

This is why your follow-up doctor visits are important. You’re most likely to find out the cancer has spread if your doctor tests your blood and finds high levels of prostate-specific antigen, or PSA. They might also find it with a digital rectal exam or on an X-ray or other test. If you do have symptoms, they often include trouble peeing or blood in your urine. You might also feel very tired, short of breath, or lose weight without trying. 

You’re more likely to feel pain if the cancer has gone into your bones. Where it hurts will depend on which bones it affects. For instance, you might feel hip or back pain if cancer has spread into your pelvic bones.

Living With Cancer

No matter which treatments you decide to pursue, advanced prostate cancer is bound to take a toll on your day-to-day life. Loss of bladder control (incontinence), fatigue, and erectile dysfunction often go hand-in-hand with treatment. Men who have hormonal therapy may have hot flashes (similar to what many women have during menopause) or gain weight. Cancer that has spread to your bones can also be painful. 

Be sure to tell you doctor about any pain or side effects. There are a wide array of medications and procedures that can help you feel better.

Self-care is also important: Take naps to fight fatigue and try to do some light exercise, like walking, to keep your energy levels up. Being active can also help combat weight gain, especially if you add some strength training to your routine. Check with your doctor first to make sure it's safe for you to exercise. They may suggest you work with a physical therapist. 

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Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed. These rates can’t tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they can’t predict what will happen in any particular person’s case. These statistics can be confusing and may lead you to have more questions. Ask your doctor, who is familiar with your situation, how these numbers may apply to you.

What is a 5-year relative survival rate?

A relative survival rate compares people with the same type and stage of cancer to people in the overall population. For example, if the 5-year relative survival rate for a specific stage of prostate cancer is 90%, it means that men who have that cancer are, on average, about 90% as likely as men who don’t have that cancer to live for at least 5 years after being diagnosed.

Where do these numbers come from?

The American Cancer Society relies on information from the SEER (Surveillance, Epidemiology, and End Results) database, maintained by the National Cancer Institute (NCI), to provide survival statistics for different types of cancer.

The SEER database tracks 5-year relative survival rates for prostate cancer in the United States, based on how far the cancer has spread. The SEER database, however, does not group cancers by AJCC TNM stages (stage 1, stage 2, stage 3, etc.). Instead it groups cancers into localized, regional, and distant stages.

  • Localized: There is no sign that the cancer has spread outside the prostate.
  • Regional: The cancer has spread outside the prostate to nearby structures or lymph nodes.
  • Distant: The cancer has spread to parts of the body farther from the prostate, such as the lungs, liver, or bones.

Prostate cancer 5-year relative survival rates

These numbers are based on men diagnosed with prostate cancer between 2011 and 2017.

SEER Stage

5-year Relative Survival Rate

Localized

>99%

Regional

>99%

Distant

31%

All SEER stages combined

98%

Understanding the numbers

  • These numbers apply only to the stage of the cancer when it is first diagnosed. They do not apply later on if the cancer grows, spreads, or comes back after treatment.
  • These numbers don’t take everything into account. Survival rates are grouped based on how far the cancer has spread, but your age and overall health, test results such as the PSA level and Grade Group of the cancer, how well the cancer responds to treatment, and other factors can also affect your outlook.
  • Men now being diagnosed with prostate cancer may have a better outlook than these numbers show. Treatments improve over time, and these numbers are based on men who were diagnosed and treated at least five years earlier.

American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.

Early Detection, Diagnosis, and Staging

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  • Prostate Cancer Stages
  • Risk Groups for Localized Prostate Cancer
  • Survival Rates for Prostate Cancer
  • Questions To Ask About Prostate Cancer

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Can prostate cancer be cured if it has spread to lymph nodes?

The most common sites of prostate cancer spread are to the lymph nodes and bones. This is also called metastatic prostate cancer. Currently, no treatments can cure advanced/metastatic prostate cancer.

What is the survival rate for prostate cancer that has spread to lymph nodes?

Stage-4 Prostate Cancer (IV) This is the last stage of prostate cancer and describes a tumor that has spread to other parts of the body, including the lymph nodes, lungs, liver, bones, or bladder. For these cancers, the 5-year survival rate is 29%.

What happens when prostate cancer spreads to the lymph nodes?

Prostate cancer can spread to the lymph nodes in the groin area, or to other parts of the body. The most common symptoms are swelling and pain around the area where the cancer has spread. Cancer cells can stop lymph fluid from draining away. This might lead to swelling in the legs due to fluid build up in that area.

How long do you live when cancer spreads to lymph nodes?

A patient with widespread metastasis or with metastasis to the lymph nodes has a life expectancy of less than six weeks. A patient with metastasis to the brain has a more variable life expectancy (one to 16 months) depending on the number and location of lesions and the specifics of treatment.