Most overdoses cause no immediate symptoms. If the overdose is very large, symptoms develop in 4 stages: Show
If toxicity results from multiple smaller doses taken over time, the first indication of the problem may be abnormal liver function, sometimes with jaundice and/or bleeding. Diagnosis of Acetaminophen Poisoning
The doctor considers acetaminophen poisoning in people who may be attempting suicide Suicidal Behavior Suicide is death caused by an intentional act of self-harm that is designed to be lethal. Suicidal behavior includes completed suicide, attempted suicide, and suicidal ideation. Suicide usually... read more , in children who were given cough and cold preparations containing acetaminophen, and in people who may have accidentally ingested acetaminophen. Doctors can predict the likelihood of acetaminophen toxicity by the amount ingested or, more accurately, by the level of acetaminophen in the person's blood. The blood level, measured between 4 hours and 24 hours after ingestion, may help predict the severity of the liver damage. Blood tests of liver function can sometimes help, particularly if toxicity may have resulted from doses repeated over time. Treatment of Acetaminophen Poisoning
If acetaminophen was taken within the previous several hours, activated charcoal may be given. If the level of acetaminophen in the blood is high, the drug acetylcysteine is generally given by mouth or by vein to reduce the toxicity of the acetaminophen. Acetylcysteine is given repeatedly, for one to several days. This antidote helps prevent liver injury but does not reverse injury that has already occurred. Therefore, acetylcysteine must be given before liver injury occurs. Treatment for liver failure Treatment Liver failure is severe deterioration in liver function. Liver failure is caused by a disorder or substance that damages the liver. Most people have jaundice (yellow skin and eyes), feel tired... read more or liver transplant Liver Transplantation Liver transplantation is the surgical removal of a healthy liver or sometimes a part of a liver from a living person and then its transfer into a person whose liver no longer functions. (See... read more may also be necessary. If toxicity results from multiple smaller doses taken over time, predicting the course of liver injury is difficult. Acetylcysteine is given if tests indicate liver damage is possible and sometimes if liver damage has already developed. More InformationThe following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
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